Tocilizumab is associated with reduction of the risk of ICU admission and mortality in patients with SARS-CoV-2 infection (preprint)

Background In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one of the major burdens in the management around the world, therefore, clinical strategies to avoid ICU admission are needed. Objective We aimed to describe the influence of tocilizumab on the need of transfer to ICU or death in non-critically ill patients. Methods A retrospective study of 171 patients with SARS-CoV-2 infection that did not qualify as requiring transfer to ICU during the first 24h after admission to a conventional ward, were included. The criteria to receive tocilizumab was radiological impairment, oxygen demand or an increasing of inflammatory parameters, however, the ultimate decision was left to the attending physician judgement. The primary outcome was the need of ICU admission or death whichever came first. Results 77 patients received tocilizumab and 94 did not. The tocilizumab group had less ICU admissions (10.3% vs. 27.6%, P= 0.005) and need of invasive ventilation (0 vs 13.8%, P=0.001). In the multivariable analysis, tocilizumab remained as a protective variable (OR: 0.03, CI 95%: 0.007-0*1, P=0.0001) of ICU admission or death. Conclusions Tocilizumab in the early stages of the inflammatory flare, could avoid an important number of ICU admissions and mechanical ventilation use. The mortality rate of 10.3% among patients receiving tocilizumab appears to be lower than other reports.

Inequality in times of pandemics: How online media are starting to treat the economic consequences of the coronavirus crisis

In December 2019, Chinese authorities informed the World Health Organization about a new coronavirus disease that would come to be called Covid-19. The world media began reporting on this new virus and its consequences. However, reports about Covid-19 would not appear in the European and American media until their societies became aware of both the health and economic consequences of Covid-19 in March 2020. This article analyzes the online media coverage of economic inequality. The goal is to understand the formation of the public agenda, based on the impact of the disease on social classes as the main factor generating greater inequality levels, in particular inequality of opportunities as the most remarkable topic during the first stage of the pandemic. According to the first results of this content analysis, the social class divide will be deepened by the pandemic. For this study, a tool was designed to analyze both the manifest and latent content of the items. Using content analysis, an analysis of news published by 33 digital media in both Europe and Latin America from March 14 to April 14, 2020 was conducted. The results of this study show that income inequality appears as the core variable of the problem, although social classes remain important. The imbalanced access to health and education public services also receives continuous coverage in the media. However, poverty as a consequence of this situation remains an uncomfortable issue and tends to be presented in an undramatized way.